7ZI4

Cryo-EM structure of the human INO80 complex bound to a WT nucleosome

Exp. Method EM
Resolution, Å 3.2
Release Date 2023-04-19
Update Date 2023-04-19
Authors Vance, N.R., Ayala, R., Willhoft, O., Tvardovskiy, A., McCormack, E.A., Bartke, T., Zhang, X., Wigley, D.B.
Publication PMID:
doi
Related structures 6HTS, 6FML
RCSB PDB 7ZI4
EMDB EMD-14737
Q-score 0.462
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal M canonical H3 Homo sapiens P68431
Distal I canonical H3 Homo sapiens P68431
H4 Proximal N canonical H4 Homo sapiens P62805
Distal J canonical H4 Homo sapiens P62805
H2A Proximal O canonical H2A Homo sapiens P04908
Distal K canonical H2A Homo sapiens P04908
H2B Proximal P canonical H2B Homo sapiens P06899
Distal L canonical H2B Homo sapiens P06899
Other proteins:
Chain Name UID
A RuvB-like 1 Q9Y265
B RuvB-like 2 Q9Y230
C RuvB-like 1 Q9Y265
D RuvB-like 2 Q9Y230
E RuvB-like 1 Q9Y265
F RuvB-like 2 Q9Y230
G Chromatin-remodeling ATPase INO80 Q9ULG1
H Actin-related protein 5 Q9H9F9
Q INO80 complex subunit C Q6PI98
R INO80 complex subunit B Q9C086
DNA:
Chain Variant Length
X 601 158
Y 601 158

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.