6FML

CryoEM Structure INO80core Nucleosome complex

Exp. Method EM
Resolution, Å 4.34
Release Date 2018-04-25
Update Date 2019-12-11
Authors Eustermann, S., Schall, K., Kostrewa, D., Lakomek, K., Strauss, M., Moldt, M., Hopfner, K.P.
Publication PMID: 29643509
doi 10.1038/s41586-018-0029-y
Related structures 6FHS
RCSB PDB 6FML
EMDB EMD-4277
Q-score 0.33
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal M canonical H3 Homo sapiens Q71DI3
Distal Q canonical H3 Homo sapiens Q71DI3
H4 Proximal N canonical H4 Homo sapiens P62805
Distal R canonical H4 Homo sapiens P62805
H2A Proximal O canonical H2A Homo sapiens P0C0S8
Distal S canonical H2A Homo sapiens P0C0S8
H2B Proximal P canonical H2B Homo sapiens P62807
Distal T canonical H2B Homo sapiens P62807
Other proteins:
Chain Name UID
A RuvB-like helicase G0RYI5
B RuvB-like helicase G0RYI5
C RuvB-like helicase G0RYI5
D RuvB-like helicase G0RYC2
E RuvB-like helicase G0RYC2
F RuvB-like helicase G0RYC2
G Ino80 NA
H les2 G0RY01
I Ies6 G0S590
J Actin related protein 5 G0S589
DNA:
Chain Variant Length
K 601 144
L 601 144

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.