6HTS

Cryo-EM structure of the human INO80 complex bound to nucleosome

Exp. Method EM
Resolution, Å 4.8
Release Date 2018-11-07
Update Date 2019-12-11
Authors Ayala, R., Willhoft, O., Aramayo, R.J., Wilkinson, M., McCormack, E.A., Ocloo, L., Wigley, D.B., Zhang, X.
Publication PMID: 29643506
doi 10.1038/s41586-018-0021-6
RCSB PDB 6HTS
EMDB EMD-3954
Q-score 0.181
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal I canonical H3 Homo sapiens P68431
Distal M canonical H3 Homo sapiens P68431
H4 Proximal J canonical H4 Homo sapiens P62805
Distal N canonical H4 Homo sapiens P62805
H2A Proximal K canonical H2A Homo sapiens P04908
Distal O canonical H2A Homo sapiens P04908
H2B Proximal L canonical H2B Homo sapiens P06899
Distal P canonical H2B Homo sapiens P06899
Other proteins:
Chain Name UID
A RuvB-like 1 Q9Y265
B RuvB-like 2 Q9Y230
C RuvB-like 1 Q9Y265
D RuvB-like 2 Q9Y230
E RuvB-like 1 Q9Y265
F RuvB-like 2 Q9Y230
G Chromatin-remodeling ATPase INO80 Q9ULG1
H Actin-related protein 5 Q9H9F9
R INO80 complex subunit B Q9C086
DNA:
Chain Variant Length
X 601 150
Y 601 150

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.