8OOA

CryoEM Structure INO80core Hexasome complex Hexasome refinement state1

Exp. Method EM
Resolution, Å 3.18
Release Date 2023-07-26
Update Date 2023-08-02
Authors Zhang, M., Jungblut, A., Kunert, F., Hauptmann, L., Hoffmann, T., Kolesnikova, O., Metzner, F., Moldt, M., Weis, F., DiMaio, F., Hopfner, K.P., Eustermann, S.
Publication PMID: 37384673
doi 10.1126/science.adf6287
Related structures 8OO7, 8OOA
RCSB PDB 8OOA
EMDB EMD-17008
Q-score 0.525
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal M canonical H3 Homo sapiens P68431
Distal Q canonical H3 Homo sapiens P68431
H4 Proximal N canonical H4 Homo sapiens P62805
Distal R canonical H4 Homo sapiens P62805
H2A Proximal O canonical H2A Homo sapiens Q93077
H2B Proximal P canonical H2B Homo sapiens P62807
DNA:
Chain Variant Length
K 601 102
L 601 102

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.