6T7B

Structure of human Sox2 transcription factor in complex with a nucleosome

Exp. Method EM
Resolution, Å 5.1
Release Date 2020-04-29
Update Date 2020-05-13
Authors Dodonova, S.O., Zhu, F., Dienemann, C., Taipale, J., Cramer, P.
Publication PMID: 32350470
doi 10.1038/s41586-020-2195-y
Related structures 6T79, 6T7A, 6T7C, 6T7D, 6T78
RCSB PDB 6T7B
EMDB EMD-10392
Q-score 0.217
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal A canonical H3 Homo sapiens Q71DI3
Distal E canonical H3 Homo sapiens Q71DI3
H4 Proximal B canonical H4 Homo sapiens P62805
Distal F canonical H4 Homo sapiens P62805
H2A Proximal C canonical H2A Homo sapiens P04908
Distal G canonical H2A Homo sapiens P04908
H2B Proximal D canonical H2B Homo sapiens O60814
Distal H canonical H2B Homo sapiens O60814
Other proteins:
Chain Name UID
K Transcription factor SOX-2 P48431
DNA:
Chain Variant Length
I DNA-1 95
J DNA-1 95

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.