8THU

Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1

Exp. Method EM
Resolution, Å 3.1
Release Date 2023-09-06
Update Date 2023-09-06
Authors Abini-Agbomson, S., Gretarsson, K., Shih, R.M., Hsieh, L., Lou, T., De Ioannes, P., Vasilyev, N., Lee, R., Wang, M., Simon, M.D., Armache, J.P., Nudler, E., Narlikar, G., Liu, S., Lu, C., Armache, K.J.
Publication PMID: 37595555
doi 10.1016/j.molcel.2023.07.020
RCSB PDB 8THU
EMDB EMD-41272
Q-score 0.508
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal E canonical H3 Xenopus laevis P84233
Distal A canonical H3 Xenopus laevis P84233
H4 Proximal F canonical H4 Xenopus laevis P62799
Distal B canonical H4 Xenopus laevis P62799
H2A Proximal G H2A.Z Homo sapiens P0C0S5
Distal C H2A.Z Homo sapiens P0C0S5
H2B Proximal H canonical H2B Xenopus laevis P02281
Distal D canonical H2B Xenopus laevis P02281
DNA:
Chain Variant Length
I 601 145
J 601 146

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.