| Exp. Method | EM |
|---|---|
| Resolution, Å | 4.1 |
| Release Date | 2024-02-07 |
| Update Date | 2024-05-15 |
| Authors | Fianu, I., Ochmann, M., Walshe, J.L., Dybkov, O., Cruz, J.N., Urlaub, H., Cramer, P. |
| doi | 10.1038/s41586-024-07269-4 |
| Publication | PMID: 38570683 |
| Related structures | |
| RCSB PDB | 8RBX |
| EMDB | EMD-19038 |
| Q-score | 0.037 |
| Side | Chain | HistoneDB Variant | Taxa | UID | |
|---|---|---|---|---|---|
| H3 | Proximal | M | canonical H3 | Homo sapiens | Q6NXT2 |
| Distal | S | canonical H3 | Homo sapiens | Q6NXT2 | |
| H4 | Proximal | O | canonical H4 | Homo sapiens | P62805 |
| Distal | U | canonical H4 | Homo sapiens | P62805 | |
| H2A | Proximal | Q | canonical H2A | Homo sapiens | P0C0S8 |
| Distal | V | canonical H2A | Homo sapiens | P0C0S8 | |
| H2B | Proximal | R | canonical H2B | Homo sapiens | P06899 |
| Distal | W | canonical H2B | Homo sapiens | P06899 |
| Chain | Name | UID |
|---|---|---|
| A | DNA-directed RNA polymerase subunit | A0A8D1DPV6 |
| B | DNA-directed RNA polymerase subunit beta | I3LGP4 |
| C | DNA-directed RNA polymerase II subunit RPB3 | I3LCH3 |
| D | RNA polymerase II subunit D | A0A287ADR4 |
| E | DNA-directed RNA polymerase II subunit E | I3LSI7 |
| F | DNA-directed RNA polymerases I, II, and III subunit RPABC2 | A0A4X1VEK9 |
| G | DNA-directed RNA polymerase II subunit RPB7 | A0A4X1VKG7 |
| H | DNA-directed RNA polymerases I, II, and III subunit RPABC3 | I3LCB2 |
| I | DNA-directed RNA polymerase II subunit RPB9 | P60899 |
| J | DNA-directed RNA polymerases I, II, and III subunit RPABC5 | A0A4X1VYD0 |
| K | DNA-directed RNA polymerase II subunit RPB11-a | F1RKE4 |
| L | RNA polymerase II subunit K | A0A8D0JYF1 |
| Y | DNA-directed RNA polymerase subunit | A0A8D1DPV6 |
| Z | Transcription elongation factor SPT5 | O00267 |
| a | Integrator complex subunit 1 | Q8N201 |
| b | Integrator complex subunit 2 | Q9H0H0 |
| d | Integrator complex subunit 4 | Q96HW7 |
| e | Integrator complex subunit 5 | Q6P9B9 |
| f | Integrator complex subunit 6 | Q9UL03 |
| g | Integrator complex subunit 7 | Q9NVH2 |
| h | Integrator complex subunit 8 | Q75QN2 |
| i | Integrator complex subunit 9 | Q9NV88 |
| j | Integrator complex subunit 10 | Q9NVR2 |
| k | Integrator complex subunit 11 | Q5TA45 |
| m | Integrator complex subunit 13 | Q9NVM9 |
| n | Integrator complex subunit 14 | Q96SY0 |
| o | Integrator complex subunit 15 | Q96N11 |
| p | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform | P30153 |
| q | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | P67775 |
| r | DSS1 | NA |
| u | Negative elongation factor A | Q9H3P2 |
| v | NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B | Q8WX92 |
| w | Negative elongation factor C/D | Q8IXH7 |
| Chain | Variant | Length |
|---|---|---|
| N | 601 | 148 |
| T | 601 | 161 |
H3
H4
H2A
H2B
DNA
Other