8OL1

cGAS-Nucleosome in complex with SPSB3-ELOBC (composite structure)

Exp. Method EM
Resolution, Å 3.5
Release Date 2024-02-14
Update Date 2024-04-10
Authors Xu, P., Liu, Y., Liu, C., Guey, B., Li, L., Melenec, P., Ricci, J., Ablasser, A.
Publication PMID: 38418882
doi 10.1038/s41586-024-07112-w
RCSB PDB 8OL1
EMDB EMD-16936
Q-score 0.4
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal A canonical H3 Homo sapiens Q71DI3
Distal E canonical H3 Homo sapiens Q71DI3
H4 Proximal B canonical H4 Homo sapiens P62805
Distal F canonical H4 Homo sapiens P62805
H2A Proximal C canonical H2A Homo sapiens Q96KK5
Distal G canonical H2A Homo sapiens Q99878
H2B Proximal D canonical H2B Homo sapiens Q93079
Distal H canonical H2B Homo sapiens Q99877
Other proteins:
Chain Name UID
K Cyclic GMP-AMP synthase Q8N884
L SPRY domain-containing SOCS box protein 3 Q6PJ21
M Elongin-C Q15369
N Elongin-B Q15370
DNA:
Chain Variant Length
I 601 145
J 601 145

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.