8OF4

Nucleosome Bound human SIRT6 (Composite)

Exp. Method EM
Resolution, Å 2.94
Release Date 2023-08-09
Update Date 2024-03-13
Authors Smirnova, E., Bignon, E., Schultz, P., Papai, G., Ben Shem, A.
Publication PMID: 38415718
doi 10.7554/eLife.87989
RCSB PDB 8OF4
EMDB EMD-16845
Q-score 0.446
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal A canonical H3 Xenopus laevis P84233
Distal E canonical H3 Xenopus laevis P84233
H4 Proximal B canonical H4 Xenopus laevis P62799
Distal F canonical H4 Xenopus laevis P62799
H2A Proximal C canonical H2A Xenopus laevis P06897
Distal G canonical H2A Xenopus laevis P06897
H2B Proximal D canonical H2B Xenopus laevis P02281
Distal H canonical H2B Xenopus laevis P02281
Other proteins:
Chain Name UID
L NAD-dependent protein deacylase sirtuin-6 Q8N6T7
DNA:
Chain Variant Length
I 601 145
J 601 145

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.