8KB5

Cryo-EM structure of the human nucleosome containing H3.8

Exp. Method EM
Resolution, Å 2.26133
Release Date 2023-10-18
Update Date 2023-12-27
Authors Hirai, S., Kujirai, T., Akatsu, M., Ogasawara, M., Ehara, H., Sekine, S.I., Ohkawa, Y., Takizawa, Y., Kurumizaka, H.
Publication PMID: 37757444
doi 10.1093/jb/mvad069
RCSB PDB 8KB5
EMDB EMD-37070
Q-score 0.655
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal A H3.3 Homo sapiens P84243
Distal E H3.3 Homo sapiens P84243
H4 Proximal B canonical H4 Homo sapiens P62805
Distal F canonical H4 Homo sapiens P62805
H2A Proximal C canonical H2A Homo sapiens P04908
Distal G canonical H2A Homo sapiens P04908
H2B Proximal D canonical H2B Homo sapiens P06899
Distal H canonical H2B Homo sapiens P06899
DNA:
Chain Variant Length
I 601L 145
J 601L 145

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.