8H1T

Cryo-EM structure of BAP1-ASXL1 bound to chromatosome

Exp. Method EM
Resolution, Å 3
Release Date 2023-02-01
Update Date 2023-04-19
Authors Ge, W., Yu, C., Li, J., Yu, Z., Li, X., Zhang, Y., Liu, C.P., Li, Y., Tian, C., Zhang, X., Li, G., Zhu, B., Xu, R.M.
Publication PMID: 36991118
doi 10.1038/s41586-023-05841-y
RCSB PDB 8H1T
EMDB EMD-34431
Q-score 0.435
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal E canonical H3 Homo sapiens P68431
Distal A canonical H3 Homo sapiens P68431
H4 Proximal F canonical H4 Homo sapiens P62805
Distal B canonical H4 Homo sapiens P62805
H2A Proximal G canonical H2A Homo sapiens P20671
Distal C canonical H2A Homo sapiens P20671
H2B Proximal H canonical H2B Homo sapiens Q16778
Distal D canonical H2B Homo sapiens Q16778
H1:
Chain HistoneDB Variant UID
K H1.4 P10412
Other proteins:
Chain Name UID
L Ubiquitin carboxyl-terminal hydrolase BAP1 Q92560
M Ubiquitin P0CG47
N Polycomb group protein ASXL1 Q8IXJ9
DNA:
Chain Variant Length
I 601 167
J 601 167

H3

H4

H2A

H2B

H1

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.