8CBN

structure of LEDGF/p75 PWWP domain bound to the H3K36 trimethylated dinucleosome

Exp. Method EM
Resolution, Å 3.34
Release Date 2023-12-27
Update Date 2023-12-27
Authors Koutna, E., Lux, V., Kouba, T., Skerlova, J., Novacek, J., Srb, P., Hexnerova, R., Svachova, H., Kukacka, Z., Novak, P., Fabry, M., Poepsel, S., Veverka, V.
Publication PMID: 37615563
doi 10.1093/nar/gkad674
RCSB PDB 8CBN
EMDB EMD-16546
Q-score 0.392
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal A canonical H3 Xenopus laevis P84233
Distal E canonical H3 Xenopus laevis P84233
H4 Proximal B canonical H4 Xenopus laevis P62799
Distal F canonical H4 Xenopus laevis P62799
H2A Proximal C canonical H2A Xenopus laevis P06897
Distal G canonical H2A Xenopus laevis P06897
H2B Proximal D canonical H2B Xenopus laevis P02281
Distal H canonical H2B Xenopus laevis P02281
Other proteins:
Chain Name UID
K PC4 and SFRS1-interacting protein O75475
L PC4 and SFRS1-interacting protein O75475
DNA:
Chain Variant Length
I 601 150
J 601 150

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.