8B0A

Cryo-EM structure of ALC1 bound to an asymmetric, site-specifically PARylated nucleosome

Exp. Method EM
Resolution, Å 3
Release Date 2023-09-20
Update Date 2024-04-03
Authors Bacic, L., Gaullier, G., Mohapatra, J., Mao, G., Brackmann, K., Panfilov, M., Liszczak, G., Sabantsev, A., Deindl, S.
Publication PMID: 38307862
doi 10.1038/s41467-024-45237-8
Related structures 7otq
RCSB PDB 8B0A
EMDB EMD-15777
Q-score 0.483
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal A canonical H3 Xenopus laevis P84233
Distal E canonical H3 Xenopus laevis P84233
H4 Proximal B canonical H4 Xenopus laevis P62799
Distal F canonical H4 Xenopus laevis P62799
H2A Proximal C canonical H2A Xenopus laevis P06897
Distal G canonical H2A Xenopus laevis P06897
H2B Proximal D canonical H2B Xenopus laevis P02281
Distal H canonical H2B Xenopus laevis P02281
Other proteins:
Chain Name UID
K Chromodomain-helicase-DNA-binding protein 1-like Q86WJ1
DNA:
Chain Variant Length
I 601 149
J 601 149

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.