8AV6

CryoEM structure of INO80 core nucleosome complex in closed grappler conformation

Exp. Method EM
Resolution, Å 4.68
Release Date 2022-12-14
Update Date 2022-12-28
Authors Kunert, F., Metzner, F.J., Jung, J., Hopfler, M., Woike, S., Schall, K., Kostrewa, D., Moldt, M., Chen, J.X., Bantele, S., Pfander, B., Eustermann, S., Hopfner, K.P.
Publication PMID: 36490333
doi 10.1126/sciadv.add3189
RCSB PDB 8AV6
EMDB EMD-4278
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal M canonical H3 Homo sapiens Q71DI3
Distal Q canonical H3 Homo sapiens Q71DI3
H4 Proximal N canonical H4 Homo sapiens P62805
Distal R canonical H4 Homo sapiens P62805
H2A Proximal O canonical H2A Homo sapiens P0C0S8
Distal S canonical H2A Homo sapiens P0C0S8
H2B Proximal P canonical H2B Homo sapiens P62807
Distal T canonical H2B Homo sapiens P62807
Other proteins:
Chain Name UID
A RuvB-like helicase G0RYI5
B RuvB-like helicase G0RYI5
C RuvB-like helicase G0RYI5
D RuvB-like helicase G0RYC2
E RuvB-like helicase G0RYC2
F RuvB-like helicase G0RYC2
G Ino80 NA
H PAPA-1 domain-containing protein G0RY01
I YL1_C domain-containing protein G0S590
J DASH complex subunit DAD4 G0S589
DNA:
Chain Variant Length
K 601 152
L 601 152

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.