7YQK

cryo-EM structure of gammaH2AXK15ub-H4K20me2 nucleosome bound to 53BP1

Exp. Method EM
Resolution, Å 3.38
Release Date 2022-08-17
Update Date 2023-02-15
Authors Ai, H., Chu, G.C., Gong, Q., Tong, Z.B., Deng, Z., Liu, X., Yang, F., Xu, Z., Li, J.B., Tian, C., Liu, L.
Publication PMID: 36166692
doi 10.1021/jacs.2c06156
RCSB PDB 7YQK
EMDB EMD-34028
Q-score 0.424
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal A canonical H3 Homo sapiens P68431
Distal E canonical H3 Homo sapiens P68431
H4 Proximal B canonical H4 Homo sapiens P62805
Distal F canonical H4 Homo sapiens P62805
H2A Proximal C H2A.X Homo sapiens P16104
Distal G H2A.X Homo sapiens P16104
H2B Proximal D canonical H2B Homo sapiens O60814
Distal H canonical H2B Homo sapiens O60814
Other proteins:
Chain Name UID
K UDR motif of 53BP1 Q12888
N TP53-binding protein 1 Q12888
O Polyubiquitin-B P0CG47
DNA:
Chain Variant Length
I 601 145
J 601 145

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.