7XZZ

Cryo-EM structure of the nucleosome in complex with p53

Exp. Method EM
Resolution, Å 4.07
Release Date 2022-10-12
Update Date 2023-02-15
Authors Nishimura, M., Takizawa, Y., Nozawa, K., Kurumizaka, H.
Publication PMID: 36714865
doi 10.1093/pnasnexus/pgac177
RCSB PDB 7XZZ
EMDB EMD-33535
Q-score 0.192
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal A canonical H3 Homo sapiens P68431
Distal E canonical H3 Homo sapiens P68431
H4 Proximal B canonical H4 Homo sapiens P62805
Distal F canonical H4 Homo sapiens P62805
H2A Proximal C canonical H2A Homo sapiens P04908
Distal G canonical H2A Homo sapiens P04908
H2B Proximal D canonical H2B Homo sapiens P06899
Distal H canonical H2B Homo sapiens P06899
Other proteins:
Chain Name UID
K Cellular tumor antigen p53 P04637
L Cellular tumor antigen p53 P04637
M Cellular tumor antigen p53 P04637
N Cellular tumor antigen p53 P04637
DNA:
Chain Variant Length
I 601 155
J 601 155

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.