7XPX

Cryo-EM structure of the histone methyltransferase SET8 bound to H4K20Ecx-nucleosome

Exp. Method EM
Resolution, Å 3.2
Release Date 2022-06-01
Update Date 2022-06-01
Authors Shi, L., Huang, L., Long, H., Song, A., Zhou, Z.
Publication PMID: 35532550
doi 10.1096/fj.202101821R
RCSB PDB 7XPX
EMDB EMD-33385
Q-score 0.475
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal E canonical H3 Xenopus laevis P84233
Distal A canonical H3 Xenopus laevis P84233
H4 Proximal F canonical H4 Xenopus laevis P62799
Distal B canonical H4 Xenopus laevis P62799
H2A Proximal G canonical H2A Xenopus laevis P06897
Distal C canonical H2A Xenopus laevis P06897
H2B Proximal H canonical H2B Xenopus laevis P02281
Distal D canonical H2B Xenopus laevis P02281
Other proteins:
Chain Name UID
K N-lysine methyltransferase KMT5A Q9NQR1
DNA:
Chain Variant Length
I 601L 145
J 601L 145

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.