7W9V

Cryo-EM structure of nucleosome in complex with p300 acetyltransferase catalytic core (complex I)

Exp. Method EM
Resolution, Å 3.95
Release Date 2022-07-13
Update Date 2024-10-23
Authors Hatazawa, S., Liu, J., Takizawa, Y., Zandian, M., Negishi, L., Kutateladze, T.G., Kurumizaka, H.
doi 10.1016/j.isci.2022.104563
Publication PMID: 35754730
Related structures
RCSB PDB 7W9V
EMDB EMD-32373
Q-score 0.307
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal A canonical H3 Homo sapiens P68431
Distal E canonical H3 Homo sapiens P68431
H4 Proximal B canonical H4 Homo sapiens P62805
Distal F canonical H4 Homo sapiens P62805
H2A Proximal C canonical H2A Homo sapiens P04908
Distal G canonical H2A Homo sapiens P04908
H2B Proximal D canonical H2B Homo sapiens P06899
Distal H canonical H2B Homo sapiens P06899
Other proteins:
Chain Name UID
K Histone acetyltransferase p300 Q09472
DNA:
Chain Variant Length
I 601 145
J 601 145

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

-40-30-20-10010203040-40-30-20-10010203040Coordinate X, ACoordinate Y, AH3H4H2AH2BDNA
Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.