7VZ4

Cryo-EM structure of human nucleosome core particle composed of the Widom 601L DNA sequence

Exp. Method EM
Resolution, Å 1.89
Release Date 2023-05-17
Update Date 2023-05-17
Authors Takizawa, Y., Ho, C.H., Sato, S., Danev, R., Kurumizaka, H.
Publication PMID:
doi
RCSB PDB 7VZ4
EMDB EMD-32220
Q-score 0.724
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal A canonical H3 Homo sapiens P68431
Distal E canonical H3 Homo sapiens P68431
H4 Proximal B canonical H4 Homo sapiens P62805
Distal F canonical H4 Homo sapiens P62805
H2A Proximal C canonical H2A Homo sapiens P04908
Distal G canonical H2A Homo sapiens P04908
H2B Proximal D canonical H2B Homo sapiens P06899
Distal H canonical H2B Homo sapiens P06899
DNA:
Chain Variant Length
I 601L 145
J 601L 145

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.