7VVZ

NuA4 bound to the nucleosome

Exp. Method	EM
Resolution, Å	8.8
Release Date	2022-08-10
Update Date	2022-11-16
Authors	Qu, K., Chen, K., Wang, H., Li, X., Chen, Z.
Publication	PMID: 36198799
doi	10.1038/s41586-022-05303-x
RCSB PDB	7VVZ
EMDB	EMD-32150
Q-score	0.108

Core histones in Nucleosome-like particles:

	Side	Chain	HistoneDB Variant	Taxa	UID
H3	Proximal	A	canonical H3	Xenopus laevis	P84233
H3	Distal	O	canonical H3	Xenopus laevis	P84233
H4	Proximal	B	canonical H4	Xenopus laevis	P62799
H4	Distal	Q	canonical H4	Xenopus laevis	P62799
H2A	Proximal	N	canonical H2A	Xenopus laevis	P06897
H2A	Distal	S	canonical H2A	Xenopus laevis	P06897
H2B	Proximal	D	canonical H2B	Xenopus laevis	P02281
H2B	Distal	U	canonical H2B	Xenopus laevis	P02281

Other proteins:

Chain	Name	UID
E	Chromatin modification-related protein EAF1	Q06337
F	Actin-related protein 4	P80428
G	Actin	P60010
H	Enhancer of polycomb-like protein 1	P43572
K	SWR1-complex protein 4	P53201
L	Transcription-associated protein 1	P38811
P	Histone acetyltransferase ESA1	Q08649
T	Enhancer of polycomb-like protein 1	P43572
V	Chromatin modification-related protein YNG2	P38806
X	Epl1 arginine anchor	P43572
Y	Chromatin modification-related protein EAF6	P47128

DNA:

Chain	Variant	Length
I	601	179
W	601	180

H3

H4

H2A

H2B

DNA

Other

Orthographic Superimpose 1KX5 Show axes

Aligned nucleosome coordinates

X - Y

X - Z

Z - Y

Nucleosome reference frame definition

DNA relative twist and local base step parameters

3DNA

Relative Twist

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.

H3p chain A

H4p chain B

H2Bp chain D

H2Ap chain N

H3d chain O

H4d chain Q

H2Ad chain S

H2Bd chain U

DNA top chain W, bot chain I

Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.