7UD5

Complex between MLL1-WRAD and an H2B-ubiquitinated nucleosome

Exp. Method EM
Resolution, Å 4.25
Release Date 2022-09-21
Update Date 2022-10-05
Authors Rahman, S., Hoffmann, N.A., Worden, E.J., Smith, M.L., Namitz, K.E.W., Knutson, B.A., Cosgrove, M.S., Wolberger, C.
Publication PMID: 36095189
doi 10.1073/pnas.2205691119
Related structures 8DU4
RCSB PDB 7UD5
EMDB EMD-26454
Q-score 0.263
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal A canonical H3 Xenopus laevis P84233
Distal E canonical H3 Xenopus laevis P84233
H4 Proximal B canonical H4 Xenopus laevis P62799
Distal F canonical H4 Xenopus laevis P62799
H2A Proximal C canonical H2A Xenopus laevis P06897
Distal G canonical H2A Xenopus laevis P06897
H2B Proximal D canonical H2B Xenopus laevis P02281
Distal H canonical H2B Xenopus laevis P02281
Other proteins:
Chain Name UID
K cDNA FLJ56846, highly similar to Zinc finger protein HRX B4DIJ7
L WD repeat-containing protein 5 P61964
M Set1/Ash2 histone methyltransferase complex subunit ASH2 Q9UBL3
N Retinoblastoma-binding protein 5 Q15291
O Polyubiquitin-B P0CG47
P Protein dpy-30 homolog Q9C005
Q Protein dpy-30 homolog Q9C005
DNA:
Chain Variant Length
I 601 146
J 601 146

H3

H4

H2A

H2B

DNA

Other


Chain Bfactor Q-score Local Resolution

Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.