7U53

Nucleosome core particle with AP-site at SHL0

Exp. Method EM
Resolution, Å 4
Release Date 2022-09-07
Update Date 2025-05-14
Authors Weaver, T.M., Hoitsma, N.M., Spencer, J.J., Gakhar, L., Schnicker, N.J., Freudenthal, B.D.
doi 10.1038/s41467-022-33057-7
Publication PMID: 36104361
Related structures
RCSB PDB 7U53
EMDB EMD-26339
Q-score 0.385
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal A canonical H3 Homo sapiens Q71DI3
Distal E canonical H3 Homo sapiens Q71DI3
H4 Proximal B canonical H4 Homo sapiens P62805
Distal F canonical H4 Homo sapiens P62805
H2A Proximal C canonical H2A Homo sapiens P0C0S8
Distal G canonical H2A Homo sapiens P0C0S8
H2B Proximal D canonical H2B Homo sapiens P62807
Distal H canonical H2B Homo sapiens P62807
DNA:
Chain Variant Length
I 601 143
J 601 144

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

-40-30-20-10010203040-40-30-20-10010203040Coordinate X, ACoordinate Y, AH3H4H2AH2BDNA
Nucleosome reference frame definition

DNA relative twist and local base step parameters

TCGAGAATCCCGGTGCCGAGGCCGCTCAATTGGTCGTAGACAGCTCTAGCACCGCTTAAACGCACGTACGCXCTGTCCCCCGCGTTTTAACCGCCAAGGGGATTACTCCCTAGTCTCCAGGCACGTGTCAGATATATACATCC-1000100DNA relative twist, °-70-60-50-40-30-20-10010203040506070rTwrTwfTA pairTA stepYR step
Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.
PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLAAIHAKRVTIMPKDIQLARRIRGER0246α Nα 1α 2α 3β 1β 2405060708090100110120130