7MBM

Cryo-EM structure of MLL1-NCP (H3K4M) complex, mode01

Exp. Method EM
Resolution, Å
Release Date 2021-12-29
Update Date 2022-01-19
Authors Ayoub, A., Park, S.H., Lee, Y.T., Cho, U.S., Dou, Y.
Publication PMID: 34928138
doi 10.1021/acs.biochem.1c00603
RCSB PDB 7MBM
EMDB EMD-23738
Q-score 0.198
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal G canonical H3 Xenopus laevis P84233
Distal K canonical H3 Xenopus laevis P84233
H4 Proximal H canonical H4 Xenopus laevis P62799
Distal L canonical H4 Xenopus laevis P62799
H2A Proximal I canonical H2A Xenopus laevis P06897
Distal M canonical H2A Xenopus laevis P06897
H2B Proximal J canonical H2B Xenopus laevis P02281
Distal N canonical H2B Xenopus laevis P02281
Other proteins:
Chain Name UID
A Retinoblastoma-binding protein 5 Q15291
B WD repeat-containing protein 5 P61964
C Histone-lysine N-methyltransferase 2A Q03164
D Set1/Ash2 histone methyltransferase complex subunit ASH2 Q9UBL3
DNA:
Chain Variant Length
O 601 145
P 601 145

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.