7JO9

1:1 cGAS-nucleosome complex

Exp. Method EM
Resolution, Å 3.3
Release Date 2020-09-16
Update Date 2024-03-06
Authors Boyer, J.A., Spangler, C.J., Strauss, J.D., Cesmat, A.P., Liu, P., McGinty, R.K., Zhang, Q.
Publication PMID: 32913000
doi 10.1126/science.abd0609
RCSB PDB 7JO9
EMDB EMD-22408
Q-score 0.483
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal E canonical H3 Homo sapiens Q71DI3
Distal A canonical H3 Homo sapiens Q71DI3
H4 Proximal F canonical H4 Homo sapiens P62805
Distal B canonical H4 Homo sapiens P62805
H2A Proximal G canonical H2A Homo sapiens P0C0S8
Distal C canonical H2A Homo sapiens P0C0S8
H2B Proximal H canonical H2B Homo sapiens P62807
Distal D canonical H2B Homo sapiens P62807
Other proteins:
Chain Name UID
K Cyclic GMP-AMP synthase Q8C6L5
DNA:
Chain Variant Length
I 601 145
J 601 145

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.