7EA8

Human SETD2 bound to a nucleosome containing oncohistone mutations

Exp. Method EM
Resolution, Å 3.1
Release Date 2021-07-14
Update Date 2024-03-27
Authors Liu, Y., Zhang, Y., Xue, H., Cao, M., Bai, G., Mu, Z., Yao, Y., Sun, S., Fang, D., Huang, J.
Publication PMID: 33972509
doi 10.1038/s41421-021-00261-6
RCSB PDB 7EA8
EMDB EMD-31040
Q-score 0.509
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal A H3.3 Homo sapiens Q6PI79
Distal E H3.3 Homo sapiens Q6PI79
H4 Proximal B canonical H4 Homo sapiens P62799
Distal F canonical H4 Homo sapiens P62799
H2A Proximal C canonical H2A Homo sapiens P20671
Distal G canonical H2A Homo sapiens P20671
H2B Proximal D canonical H2B Homo sapiens P06899
Distal H canonical H2B Homo sapiens P06899
Other proteins:
Chain Name UID
L Histone-lysine N-methyltransferase SETD2 Q9BYW2
DNA:
Chain Variant Length
I 601 122
J 601 122

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.