7E8I

Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin

Exp. Method EM
Resolution, Å 3.1
Release Date 2021-06-30
Update Date 2024-03-27
Authors Dai, L., Dai, Y., Han, J., Huang, Y., Wang, L., Huang, J., Zhou, Z.
Publication PMID: 34102105
doi 10.1016/j.molcel.2021.05.010
RCSB PDB 7E8I
EMDB EMD-31020
Q-score 0.456
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal A canonical H3 Xenopus laevis P84233
Distal E canonical H3 Xenopus laevis P84233
H4 Proximal B canonical H4 Xenopus laevis P62799
Distal F canonical H4 Xenopus laevis P62799
H2A Proximal C canonical H2A Xenopus laevis P06897
Distal G canonical H2A Xenopus laevis P06897
H2B Proximal D canonical H2B Xenopus laevis P02281
Distal H canonical H2B Xenopus laevis P02281
Other proteins:
Chain Name UID
K BRCA1-associated RING domain protein 1 Q99728
L Polyubiquitin-B P0CG47
DNA:
Chain Variant Length
I 601 145
J 601 145

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.