7E8D

NSD2 E1099K mutant bound to nucleosome

Exp. Method EM
Resolution, Å 2.8
Release Date 2021-11-10
Update Date 2022-02-02
Authors Sato, K., Kumar, A., Hamada, K., Okada, C., Oguni, A., Machiyama, A., Sakuraba, S., Nishizawa, T., Nureki, O., Kono, H., Ogata, K., Sengoku, T.
Publication PMID: 34782608
doi 10.1038/s41467-021-26913-5
RCSB PDB 7E8D
EMDB EMD-31015
Q-score 0.556
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal E canonical H3 Homo sapiens P68431
Distal A canonical H3 Homo sapiens P68431
H4 Proximal F canonical H4 Homo sapiens P62805
Distal B canonical H4 Homo sapiens P62805
H2A Proximal G canonical H2A Homo sapiens P0C0S8
Distal C canonical H2A Homo sapiens P0C0S8
H2B Proximal H canonical H2B Homo sapiens P06899
Distal D canonical H2B Homo sapiens P06899
Other proteins:
Chain Name UID
K Histone-lysine N-methyltransferase NSD2 O96028
DNA:
Chain Variant Length
I 601 172
J 601 172

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.