7D20

Cryo-EM structure of SET8-CENP-A-nucleosome complex

Exp. Method EM
Resolution, Å 3
Release Date 2021-02-10
Update Date 2024-03-27
Authors Ho, C.H., Takizawa, Y., Kobayashi, W., Arimura, Y., Kimura, H., Kurumizaka, H.
Publication PMID: 33574035
doi 10.26508/lsa.202000919
RCSB PDB 7D20
EMDB EMD-30552
Q-score 0.446
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal E cenH3 Homo sapiens P49450
Distal A cenH3 Homo sapiens P49450
H4 Proximal B canonical H4 Homo sapiens P62805
Distal F canonical H4 Homo sapiens P62805
H2A Proximal C canonical H2A Homo sapiens P04908
Distal G canonical H2A Homo sapiens P04908
H2B Proximal D canonical H2B Homo sapiens P06899
Distal H canonical H2B Homo sapiens P06899
Other proteins:
Chain Name UID
K Isoform 2 of N-lysine methyltransferase KMT5A Q9NQR1
DNA:
Chain Variant Length
I 601 136
J 601 136

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.