7CRP

NSD3 bearing E1181K/T1232A dual mutation in complex with 187-bp NCP (1:1 binding mode)

Exp. Method EM
Resolution, Å 3.2
Release Date 2020-10-21
Update Date 2024-10-23
Authors Li, W., Tian, W., Yuan, G., Deng, P., Sengupta, D., Cheng, Z., Cao, Y., Ren, J., Qin, Y., Zhou, Y., Jia, Y., Gozani, O., Patel, D.J., Wang, Z.
doi 10.1038/s41586-020-03069-8
Publication PMID: 33361816
Related structures 7CRO
RCSB PDB 7CRP
EMDB EMD-30455
Q-score 0.542
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal E canonical H3 Xenopus laevis Q92133
Distal M canonical H3 Xenopus laevis Q92133
H4 Proximal F canonical H4 Xenopus laevis P62799
Distal B canonical H4 Xenopus laevis P62799
H2A Proximal G canonical H2A Xenopus laevis P06897
Distal C canonical H2A Xenopus laevis P06897
H2B Proximal H canonical H2B Xenopus tropicalis P02281
Distal D canonical H2B Xenopus tropicalis P02281
Other proteins:
Chain Name UID
I Histone-lysine N-methyltransferase NSD3 Q9BZ95
DNA:
Chain Variant Length
A 601 168
K 601 168

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

-60-40-2002040-40-20020406080Coordinate X, ACoordinate Y, AH3H4H2AH2BDNA
Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.