7AT8

Histone H3 recognition by nucleosome-bound PRC2 subunit EZH2.

Exp. Method EM
Resolution, Å 4.4
Release Date 2020-12-09
Update Date 2024-05-01
Authors Finogenova, K., Bonnet, J., Poepsel, S., Schafer, I.B., Finkl, K., Schmid, K., Litz, C., Strauss, M., Benda, C., Muller, J.
Publication PMID: 33211010
doi 10.7554/eLife.61964
RCSB PDB 7AT8
EMDB EMD-11910
Q-score 0.29
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal D canonical H3 Xenopus laevis P84233
Distal H canonical H3 Xenopus laevis P84233
H4 Proximal E canonical H4 Xenopus laevis P62799
Distal I canonical H4 Xenopus laevis P62799
H2A Proximal F canonical H2A Xenopus laevis P06897
Distal J canonical H2A Xenopus laevis P06897
H2B Proximal G canonical H2B Xenopus laevis P02281
Distal K canonical H2B Xenopus laevis P02281
Other proteins:
Chain Name UID
A Isoform 2 of Histone-lysine N-methyltransferase EZH2,Isoform 2 of Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2,Isoform 2 of Histone-lysine N-methyltransferase EZH2,Isoform 2 of Histone-lysine N-methyltransferase EZH2 Q15910
C Polycomb protein SUZ12 Q15022
DNA:
Chain Variant Length
T 601 156
U 601 156

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.