7A08

CryoEM Structure of cGAS Nucleosome complex

Exp. Method EM
Resolution, Å 3.11
Release Date 2020-09-23
Update Date 2021-02-10
Authors Michalski, S., de Oliveira Mann, C.C., Stafford, C.A., Witte, G., Bartho, J., Lammens, K., Hornung, V., Hopfner, K.P.
Publication PMID: 32911480
doi 10.1038/s41586-020-2748-0
RCSB PDB 7A08
EMDB EMD-11601
Q-score 0.533
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal h H3.3 Homo sapiens P84243
Distal d H3.3 Homo sapiens P84243
H4 Proximal e canonical H4 Homo sapiens P62805
Distal i canonical H4 Homo sapiens P62805
H2A Proximal b canonical H2A Homo sapiens Q93077
Distal f canonical H2A Homo sapiens Q93077
H2B Proximal c canonical H2B Homo sapiens P62807
Distal g canonical H2B Homo sapiens P62807
Other proteins:
Chain Name UID
a Cyclic GMP-AMP synthase Q8C6L5
DNA:
Chain Variant Length
I 601 132
J 601 131

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.