6ZHX

Cryo-EM structure of the regulatory linker of ALC1 bound to the nucleosome's acidic patch: nucleosome class.

Exp. Method EM
Resolution, Å 2.5
Release Date 2020-12-23
Update Date 2021-07-14
Authors Lehmann, L.C., Bacic, L., Hewitt, G., Brackmann, K., Sabantsev, A., Gaullier, G., Pytharopoulou, S., Degliesposti, G., Okkenhaug, H., Tan, S., Costa, A., Skehel, J.M., Boulton, S.J., Deindl, S.
Publication PMID: 33357431
doi 10.1016/j.celrep.2020.108529
RCSB PDB 6ZHX
EMDB EMD-11220
Q-score 0.625
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal A canonical H3 Xenopus laevis P84233
Distal E canonical H3 Xenopus laevis P84233
H4 Proximal B canonical H4 Xenopus laevis P62799
Distal F canonical H4 Xenopus laevis P62799
H2A Proximal C canonical H2A Xenopus laevis P06897
Distal G canonical H2A Xenopus laevis P06897
H2B Proximal D canonical H2B Xenopus laevis P02281
Distal H canonical H2B Xenopus laevis P02281
Other proteins:
Chain Name UID
K Chromodomain-helicase-DNA-binding protein 1-like Q86WJ1
L Chromodomain-helicase-DNA-binding protein 1-like Q86WJ1
DNA:
Chain Variant Length
I 601 145
J 601 145

H3

H4

H2A

H2B

DNA

Other


Chain Bfactor Q-score Local Resolution

Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.