6YOV

OCT4-SOX2-bound nucleosome - SHL+6

Exp. Method EM
Resolution, Å 3.42
Release Date 2020-05-06
Update Date 2020-07-08
Authors Michael, A.K., Grand, R.S., Isbel, L., Cavadini, S., Kozicka, Z., Kempf, G., Bunker, R.D., Schenk, A.D., Graff-Meyer, A., Pathare, G.R., Weiss, J., Matsumoto, S., Burger, L., Schubeler, D., Thoma, N.H.
Publication PMID: 32327602
doi 10.1126/science.abb0074
RCSB PDB 6YOV
EMDB EMD-10864
Q-score 0.35
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal A canonical H3 Homo sapiens P68431
Distal E canonical H3 Homo sapiens P68431
H4 Proximal B canonical H4 Homo sapiens P62805
Distal F canonical H4 Homo sapiens P62805
H2A Proximal C canonical H2A Homo sapiens P04908
Distal G canonical H2A Homo sapiens P04908
H2B Proximal D canonical H2B Homo sapiens P06899
Distal H canonical H2B Homo sapiens P06899
Other proteins:
Chain Name UID
K Green fluorescent protein,POU domain, class 5, transcription factor 1 P42212
L Transcription factor SOX-2 P48431
DNA:
Chain Variant Length
I 601 131
J 601 131

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.