6Y5D

Structure of human cGAS (K394E) bound to the nucleosome

Exp. Method EM
Resolution, Å 4.1
Release Date 2020-09-23
Update Date 2020-12-09
Authors Pathare, G.R., Decout, A., Gluck, S., Cavadini, S., Makasheva, K., Hovius, R., Kempf, G., Weiss, J., Kozicka, Z., Guey, B., Melenec, P., Fierz, B., Thoma, N.H., Ablasser, A.
Publication PMID: 32911482
doi 10.1038/s41586-020-2750-6
RCSB PDB 6Y5D
EMDB EMD-10694
Q-score 0.195
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal A canonical H3 Homo sapiens Q71DI3
Distal E canonical H3 Homo sapiens Q71DI3
H4 Proximal B canonical H4 Homo sapiens P62805
Distal F canonical H4 Homo sapiens P62805
H2A Proximal C canonical H2A Homo sapiens Q6FI13
Distal G canonical H2A Homo sapiens Q6FI13
H2B Proximal D canonical H2B Homo sapiens O60814
Distal H canonical H2B Homo sapiens O60814
Other proteins:
Chain Name UID
K Cyclic GMP-AMP synthase Q8N884
L Cyclic GMP-AMP synthase Q8N884
DNA:
Chain Variant Length
I 601 153
J 601 153
U 601 153
V 601 153

H3

H4

H2A

H2B

DNA

Other


Chain Bfactor Q-score

Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.