6X0N

Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin

Exp. Method EM
Resolution, Å 10
Release Date 2020-09-16
Update Date 2024-03-06
Authors Bilokapic, S., Suskiewicz, M.J., Ahel, I., Halic, M.
Publication PMID: 32939087
doi 10.1038/s41586-020-2725-7
RCSB PDB 6X0N
EMDB EMD-21980
Q-score 0.113
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal A canonical H3 Xenopus laevis P84233
Distal E canonical H3 Xenopus laevis P84233
H4 Proximal B canonical H4 Xenopus laevis P62799
Distal F canonical H4 Xenopus laevis P62799
H2A Proximal C canonical H2A Xenopus laevis P06897
Distal G canonical H2A Xenopus laevis P06897
H2B Proximal D canonical H2B Xenopus laevis P02281
Distal H canonical H2B Xenopus laevis P02281
Other proteins:
Chain Name UID
O Histone PARylation factor 1 Q9NWY4
P Poly [ADP-ribose] polymerase 2 Q9UGN5
R Poly [ADP-ribose] polymerase 2 Q9UGN5
DNA:
Chain Variant Length
I 601 157
J 601 157
i 601 160
j 601 160

H3

H4

H2A

H2B

DNA

Other


Chain Bfactor Q-score

Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.