6WZ5

Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin

Exp. Method EM
Resolution, Å 2.2
Release Date 2020-09-16
Update Date 2024-03-06
Authors Bilokapic, S., Suskiewicz, M.J., Ahel, I., Halic, M.
Publication PMID: 32939087
doi 10.1038/s41586-020-2725-7
RCSB PDB 6WZ5
EMDB EMD-21970
Q-score 0.504
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal E canonical H3 Xenopus laevis P84233
Distal A canonical H3 Xenopus laevis P84233
H4 Proximal F canonical H4 Xenopus laevis P62799
Distal B canonical H4 Xenopus laevis P62799
H2A Proximal G canonical H2A Xenopus laevis P06897
Distal C canonical H2A Xenopus laevis P06897
H2B Proximal H canonical H2B Xenopus laevis P02281
Distal D canonical H2B Xenopus laevis P02281
DNA:
Chain Variant Length
I 601 153
J 601 153

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.