6W5I

Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class01)

Exp. Method EM
Resolution, Å 6.9
Release Date 2021-03-31
Update Date 2022-10-12
Authors Lee, Y.T., Ayoub, A., Park, S.H., Sha, L., Xu, J., Mao, F., Zheng, W., Zhang, Y., Cho, U.S., Dou, Y.
Publication PMID: 34012049
doi 10.1038/s41467-021-23268-9
RCSB PDB 6W5I
EMDB EMD-21542
Q-score 0.135
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal K canonical H3 Xenopus laevis P84233
Distal G canonical H3 Xenopus laevis P84233
H4 Proximal L canonical H4 Xenopus laevis P62799
Distal H canonical H4 Xenopus laevis P62799
H2A Proximal M canonical H2A Xenopus laevis P06897
Distal I canonical H2A Xenopus laevis P06897
H2B Proximal N canonical H2B Xenopus laevis P02281
Distal J canonical H2B Xenopus laevis P02281
Other proteins:
Chain Name UID
A Retinoblastoma-binding protein 5 Q15291
B WD repeat-containing protein 5 P61964
C Histone-lysine N-methyltransferase 2A Q03164
D Set1/Ash2 histone methyltransferase complex subunit ASH2 Q9UBL3
DNA:
Chain Variant Length
O 601 146
P 601 146

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.