6UXW

SWI/SNF nucleosome complex with ADP-BeFx

Exp. Method	EM
Resolution, Å	8.96
Release Date	2020-03-18
Update Date	2024-03-06
Authors	Han, Y., Reyes, A.A., Malik, S., He, Y.
Publication	PMID: 32188938
doi	10.1038/s41586-020-2087-1
RCSB PDB	6UXW
EMDB	EMD-20934
Q-score	0.122

Core histones in Nucleosome-like particles:

	Side	Chain	HistoneDB Variant	Taxa	UID
H3	Proximal	V	canonical H3	Xenopus laevis	P84233
H3	Distal	R	canonical H3	Xenopus laevis	P84233
H4	Proximal	W	canonical H4	Xenopus laevis	P62799
H4	Distal	S	canonical H4	Xenopus laevis	P62799
H2A	Proximal	X	canonical H2A	Xenopus laevis	P06897
H2A	Distal	T	canonical H2A	Xenopus laevis	P06897
H2B	Proximal	Y	canonical H2B	Xenopus laevis	P02281
H2B	Distal	U	canonical H2B	Xenopus laevis	P02281

Other proteins:

Chain	Name	UID
A	Transcription regulatory protein SNF2	P22082
B	SWI/SNF chromatin-remodeling complex subunit SWI1	P09547
C	SWI/SNF chromatin-remodeling complex subunit SNF5	P18480
D	SWI/SNF complex subunit SWI3	P32591
E	SWI/SNF complex subunit SWI3	P32591
F	SWI/SNF complex subunit SWI3	P32591
G	SWI/SNF complex subunit SWI3	P32591
H	Transcription regulatory protein SNF12	P53628
I	Transcription regulatory protein SNF6	P18888
P	Actin-related protein 7	Q12406
Q	Actin-like protein ARP9	Q05123
Z	Regulator of Ty1 transposition protein 102	P53330

DNA:

Chain	Variant	Length
a	601	155
b	601	155

H3

H4

H2A

H2B

DNA

Other

Orthographic Superimpose 1KX5 Show axes

Aligned nucleosome coordinates

X - Y

X - Z

Z - Y

Nucleosome reference frame definition

DNA relative twist and local base step parameters

3DNA

Relative Twist

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.

H3d chain R

H4d chain S

H2Ad chain T

H2Bd chain U

H3p chain V

H4p chain W

H2Ap chain X

H2Bp chain Y

DNA top chain a, bot chain b

Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.