6USJ

Structure of two nucleosomes bridged by human PARP2

Exp. Method EM
Resolution, Å 10.5
Release Date 2020-10-14
Update Date 2024-03-06
Authors Gaullier, G., Roberts, G., Muthurajan, U.M., Bowerman, S., Rudolph, J., Mahadevan, J., Jha, A., Rae, P.S., Luger, K.
doi 10.1371/journal.pone.0240932
Publication PMID: 33141820
Related structures
RCSB PDB 6USJ
EMDB EMD-20864
Q-score 0.092
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal A canonical H3 Homo sapiens P68431
Distal E canonical H3 Homo sapiens P68431
H4 Proximal B canonical H4 Homo sapiens P62805
Distal F canonical H4 Homo sapiens P62805
H2A Proximal C canonical H2A Homo sapiens P04908
Distal G canonical H2A Homo sapiens P04908
H2B Proximal D canonical H2B Homo sapiens P06899
Distal H canonical H2B Homo sapiens P06899
Other proteins:
Chain Name UID
U Poly [ADP-ribose] polymerase 2 Q9UGN5
V Poly [ADP-ribose] polymerase 2 Q9UGN5
DNA:
Chain Variant Length
I 601 160
J 601 160
S 601 159
T 601 159

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

-40-2002040-40-200204060Coordinate X, ACoordinate Y, AH3H4H2AH2BDNA
Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.