6UH5

Structural basis of COMPASS eCM recognition of the H2Bub nucleosome

Exp. Method EM
Resolution, Å 3.5
Release Date 2019-11-20
Update Date 2019-12-18
Authors Hsu, P.L., Shi, H., Leonen, C., Kang, J., Chatterjee, C., Zheng, N.
Publication PMID: 31733991
doi 10.1016/j.molcel.2019.10.013
RCSB PDB 6UH5
EMDB EMD-20767
Q-score 0.372
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal E canonical H3 Xenopus laevis Q92133
Distal A canonical H3 Xenopus laevis Q92133
H4 Proximal F canonical H4 Xenopus laevis P62799
Distal B canonical H4 Xenopus laevis P62799
H2A Proximal G canonical H2A Xenopus laevis Q6AZJ8
Distal C canonical H2A Xenopus laevis Q6AZJ8
H2B Proximal H canonical H2B Xenopus laevis P02281
Distal D canonical H2B Xenopus laevis P02281
Other proteins:
Chain Name UID
K Swd3 Q6CLY5
L Bre2 Q6CTQ1
M Histone-lysine N-methyltransferase, H3 lysine-4 specific Q6CIT4
N Swd1 Q6CXF3
O Sdc1 Q6CPN6
P Sdc1 Q6CPN6
Q Ubiquitin P0CG47
X Spp1 Q6CRQ4
DNA:
Chain Variant Length
I 601 146
J 601 146

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.