6TEM

CENP-A nucleosome core particle with 145 base pairs of the Widom 601 sequence by cryo-EM

Exp. Method EM
Resolution, Å 3.9
Release Date 2020-04-08
Update Date 2020-06-10
Authors Boopathi, R., Danev, R., Khoshouei, M., Kale, S., Nahata, S., Ramos, L., Angelov, D., Dimitrov, S., Hamiche, A., Petosa, C., Bednar, J.
Publication PMID: 32313946
doi 10.1093/nar/gkaa246
RCSB PDB 6TEM
EMDB EMD-10822
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal A cenH3 Homo sapiens P49450
Distal E cenH3 Homo sapiens P49450
H4 Proximal B canonical H4 Xenopus laevis P62799
Distal F canonical H4 Xenopus laevis P62799
H2A Proximal C canonical H2A Xenopus laevis P06897
Distal G canonical H2A Xenopus laevis P06897
H2B Proximal D canonical H2B Xenopus laevis P02281
Distal H canonical H2B Xenopus laevis P02281
DNA:
Chain Variant Length
I 601 130
J 601 130

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.