6QLD

Structure of inner kinetochore CCAN-Cenp-A complex

Exp. Method EM
Resolution, Å 4.15
Release Date 2019-10-02
Update Date 2019-11-27
Authors Yan, K., Yang, J., Zhang, Z., McLaughlin, S.H., Chang, L., Fasci, D., Ehrenhofer-Murray, A.E., Heck, A.J.R., Barford, D.
Publication PMID: 31578520
doi 10.1038/s41586-019-1609-1
RCSB PDB 6QLD
EMDB EMD-4579
Q-score 0.328
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal a cenH3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) P36012
Distal e cenH3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) P36012
H4 Proximal b canonical H4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) P02309
Distal f canonical H4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) P02309
H2A Proximal i H2A.X Saccharomyces cerevisiae (strain ATCC 204508 / S288c) P04911
Distal g H2A.X Saccharomyces cerevisiae (strain ATCC 204508 / S288c) P04911
H2B Proximal d canonical H2B Saccharomyces cerevisiae (strain ATCC 204508 / S288c) P02294
Distal h canonical H2B Saccharomyces cerevisiae (strain ATCC 204508 / S288c) P02293
Other proteins:
Chain Name UID
C Inner kinetochore subunit MIF2 P35201
H Inner kinetochore subunit MCM16 Q12262
I Inner kinetochore subunit CTF3 Q12748
K Inner kinetochore subunit MCM22 P47167
L Inner kinetochore subunit IML3 P38265
N Inner kinetochore subunit CHL4 P38907
O Inner kinetochore subunit MCM21 Q06675
P Inner kinetochore subunit CTF19 Q02732
Q Inner kinetochore subunit OKP1 P53298
U Inner kinetochore subunit AME1 P38313
Y Inner kinetochore subunit NKP1 Q12493
Z Inner kinetochore subunit NKP2 Q06162
DNA:
Chain Variant Length
G 601 124
J 601 124

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.