6PA7

The cryo-EM structure of the human DNMT3A2-DNMT3B3 complex bound to nucleosome.

Exp. Method EM
Resolution, Å 2.94
Release Date 2020-06-17
Update Date 2024-03-20
Authors Xu, T.H., Liu, M., Zhou, X.E., Liang, G., Zhao, G., Xu, H.E., Melcher, K., Jones, P.A.
Publication PMID: 32968275
doi 10.1038/s41586-020-2747-1
RCSB PDB 6PA7
EMDB EMD-20281
Q-score 0.403
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal E canonical H3 Xenopus laevis P84233
Distal A canonical H3 Xenopus laevis P84233
H4 Proximal F canonical H4 Xenopus laevis P62799
Distal B canonical H4 Xenopus laevis P62799
H2A Proximal G canonical H2A Xenopus laevis P06897
Distal C canonical H2A Xenopus laevis P06897
H2B Proximal H canonical H2B Xenopus laevis P02281
Distal D canonical H2B Xenopus laevis P02281
Other proteins:
Chain Name UID
K DNA (cytosine-5)-methyltransferase 3A Q9Y6K1
N DNA (cytosine-5)-methyltransferase 3B Q9UBC3
P DNA (cytosine-5)-methyltransferase 3A Q9Y6K1
S DNA (cytosine-5)-methyltransferase 3B Q9UBC3
DNA:
Chain Variant Length
I 601 166
J 601 166

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.