6NQA

Active state Dot1L bound to the H2B-Ubiquitinated nucleosome, 1-to-1 complex

Exp. Method EM
Resolution, Å 3.54
Release Date 2019-02-20
Update Date 2020-01-08
Authors Worden, E.J., Hoffmann, N.A., Hicks, C.W., Wolberger, C.
Publication PMID: 30765112
doi 10.1016/j.cell.2019.02.002
RCSB PDB 6NQA
EMDB EMD-0480
Q-score 0.436
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal A canonical H3 Xenopus laevis P84233
Distal E canonical H3 Xenopus laevis P84233
H4 Proximal B canonical H4 Xenopus laevis P62799
Distal F canonical H4 Xenopus laevis P62799
H2A Proximal C canonical H2A Xenopus laevis P06897
Distal G canonical H2A Xenopus laevis P06897
H2B Proximal D canonical H2B Xenopus laevis P02281
Distal H canonical H2B Xenopus laevis P02281
Other proteins:
Chain Name UID
K Histone-lysine N-methyltransferase, H3 lysine-79 specific Q8TEK3
L Ubiquitin P0CG48
DNA:
Chain Variant Length
I 601 146
J 601 146

H3

H4

H2A

H2B

DNA

Other


Chain Bfactor Q-score Local Resolution

Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.