6LTJ

Structure of nucleosome-bound human BAF complex

Exp. Method EM
Resolution, Å 3.7
Release Date 2020-02-12
Update Date 2021-10-13
Authors He, S., Wu, Z., Tian, Y., Yu, Z., Yu, J., Wang, X., Li, J., Liu, B., Xu, Y.
Publication PMID: 32001526
doi 10.1126/science.aaz9761
Related structures 6LTH
RCSB PDB 6LTJ
EMDB EMD-0974
Q-score 0.007
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal E H3.3 Xenopus laevis Q6PI79
Distal A H3.3 Xenopus laevis Q6PI79
H4 Proximal F canonical H4 Xenopus laevis P62799
Distal B canonical H4 Xenopus laevis P62799
H2A Proximal G H2A.X Xenopus laevis P06897
Distal C H2A.X Xenopus laevis P06897
H2B Proximal H canonical H2B Xenopus laevis P02281
Distal D canonical H2B Xenopus laevis P02281
Other proteins:
Chain Name UID
I Transcription activator BRG1 P51532
J Actin-like protein 6A O96019
K Actin, cytoplasmic 1 P60709
L AT-rich interactive domain-containing protein 1A O14497
M SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 Q12824
N SWI/SNF complex subunit SMARCC2 Q8TAQ2
O SWI/SNF complex subunit SMARCC2 Q8TAQ2
P SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 Q96GM5
Q SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 Q969G3
R Zinc finger protein ubi-d4 Q92785
DNA:
Chain Variant Length
X 601 119
Y 601 119

H3

H4

H2A

H2B

DNA

Other


Chain Bfactor Q-score

Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.