6KIX

Cryo-EM structure of human MLL1-NCP complex, binding mode1

Exp. Method EM
Resolution, Å 4.1
Release Date 2019-09-11
Update Date 2024-03-27
Authors Xue, H., Yao, T., Cao, M., Zhu, G., Li, Y., Yuan, G., Chen, Y., Lei, M., Huang, J.
Publication PMID: 31485071
doi 10.1038/s41586-019-1528-1
RCSB PDB 6KIX
EMDB EMD-0694
Q-score 0.338
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal A canonical H3 Xenopus laevis P84233
Distal E canonical H3 Xenopus laevis P84233
H4 Proximal B canonical H4 Xenopus laevis P62799
Distal F canonical H4 Xenopus laevis P62799
H2A Proximal C canonical H2A Xenopus laevis P06897
Distal G canonical H2A Xenopus laevis P06897
H2B Proximal D canonical H2B Xenopus laevis P02281
Distal H canonical H2B Xenopus laevis P02281
Other proteins:
Chain Name UID
K Histone-lysine N-methyltransferase 2A Q03164
N Retinoblastoma-binding protein 5 Q15291
R WD repeat-containing protein 5 P61964
T Set1/Ash2 histone methyltransferase complex subunit ASH2 Q9UBL3
DNA:
Chain Variant Length
I 601 145
J 601 145

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.