6E0C

Cryo-EM structure of the CENP-A nucleosome (W601) in complex with a single chain antibody fragment

Exp. Method EM
Resolution, Å 2.63
Release Date 2019-05-22
Update Date 2019-12-18
Authors Zhou, B.R., Yadav, K.N.S., Borgnia, M., Hong, J., Cao, B., Olins, A.L., Olins, D.E., Bai, Y., Zhang, P.
Publication PMID: 31127102
doi 10.1038/s41467-019-10247-4
RCSB PDB 6E0C
EMDB EMD-8945
Q-score 0.59
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal A cenH3 Homo sapiens P49450
Distal E cenH3 Homo sapiens P49450
H4 Proximal B canonical H4 Homo sapiens P62805
Distal F canonical H4 Homo sapiens P62805
H2A Proximal C canonical H2A Homo sapiens P04908
Distal G canonical H2A Homo sapiens P04908
H2B Proximal D canonical H2B Homo sapiens P06899
Distal H canonical H2B Homo sapiens P06899
Other proteins:
Chain Name UID
M scFv NA
N scFv NA
DNA:
Chain Variant Length
I 601 146
J 601 146

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.