6C0W

Cryo-EM structure of human kinetochore protein CENP-N with the centromeric nucleosome containing CENP-A

Exp. Method EM
Resolution, Å 4
Release Date 2018-01-17
Update Date 2024-03-13
Authors Pentakota, S., Zhou, K., Smith, C., Maffini, S., Petrovic, A., Morgan, G.P., Weir, J.R., Vetter, I.R., Musacchio, A., Luger, K.
Publication PMID: 29280735
doi 10.7554/eLife.33442
Related structures 6EQT
RCSB PDB 6C0W
EMDB EMD-7326
Q-score 0.39
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal A cenH3 Homo sapiens P49450
Distal E cenH3 Homo sapiens P49450
H4 Proximal B canonical H4 Homo sapiens P62805
Distal F canonical H4 Homo sapiens P62805
H2A Proximal C canonical H2A Homo sapiens Q93077
Distal G canonical H2A Homo sapiens Q93077
H2B Proximal D canonical H2B Homo sapiens P62807
Distal H canonical H2B Homo sapiens P62807
Other proteins:
Chain Name UID
K Centromere protein N Q96H22
DNA:
Chain Variant Length
I 601 139
J 601 139

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.