5KGF

Structural model of 53BP1 bound to a ubiquitylated and methylated nucleosome, at 4.5 A resolution

Exp. Method EM
Resolution, Å 4.54
Release Date 2016-07-27
Update Date 2020-01-15
Authors Wilson, M.D., Benlekbir, S., Fradet-Turcotte, A., Sherker, A., Julien, J.P., McEwan, A., Noordermeer, S.M., Sicheri, F., Rubinstein, J.L., Durocher, D.
Publication PMID: 27462807
doi 10.1038/nature18951
RCSB PDB 5KGF
EMDB EMD-8246
Q-score 0.301
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal A canonical H3 Xenopus laevis P84233
Distal E canonical H3 Xenopus laevis P84233
H4 Proximal B canonical H4 Xenopus laevis P62799
Distal F canonical H4 Xenopus laevis P62799
H2A Proximal C canonical H2A Homo sapiens P0C0S8
Distal G canonical H2A Homo sapiens P0C0S8
H2B Proximal D canonical H2B Homo sapiens P62807
Distal H canonical H2B Homo sapiens P62807
Other proteins:
Chain Name UID
K Tumor suppressor p53-binding protein 1 Q12888
L Tumor suppressor p53-binding protein 1 Q12888
M Ubiquitin P0CG47
O Ubiquitin P0CG47
DNA:
Chain Variant Length
I 601 145
J 601 145

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.