4X23

CRYSTAL STRUCTURE OF CENP-C IN COMPLEX WITH THE NUCLEOSOME CORE PARTICLE

Exp. Method X-ray
Resolution, Å 3.5
Release Date 2014-12-10
Update Date 2023-09-27
Authors Kato, H., Jiang, J.S., Zhou, B.R., Rozendaal, M., Feng, H., Ghirlando, R., Xiao, T.S., Straight, A.F., Bai, Y.
Publication PMID: 23723239
doi 10.1126/science.1235532
Related structures 4INM
RCSB PDB 4X23
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal A canonical H3 Drosophila melanogaster P02299
Distal E canonical H3 Drosophila melanogaster P02299
H4 Proximal B canonical H4 Drosophila melanogaster P84040
Distal F canonical H4 Drosophila melanogaster P84040
H2A Proximal C canonical H2A Drosophila melanogaster P84051
Distal G canonical H2A Drosophila melanogaster P84051
H2B Proximal D canonical H2B Drosophila melanogaster P02283
Distal H canonical H2B Drosophila melanogaster P02283
Other proteins:
Chain Name UID
U CENP-C Q66LH7
V CENP-C Q66LH7
W CENP-C Q66LH7
X CENP-C Q66LH7
DNA:
Chain Variant Length
I 601 146
J 601 146
S 601 146
T 601 146

H3

H4

H2A

H2B

DNA

Other


Chain Bfactor

Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.